Endocrine Abstracts

Introduction: Type B insulin resistance is an extremely rare disease with unknown incidence. It is caused by autoantibodies, mostly IgG, against the insulin receptor that in low titres act as partial agonists. This can cause symptoms that include both hypoglycemia and hyperglycemia. It mostly affects middle-aged African-American women and the proposed treatment approaches include plasmapheresis, cyclosporine or cyclophosphamide, steroids and rituximab.Ca...

Introduction: Insulin autoimmune syndrome (Hirata’s disease) is a rare cause of hypoglycemia in Caucasians, with an estimated prevalence of 0,017 cases per 100.000 in general population. It is characterized by mostly postprandial hypoglycemia and the presence of autoantibodies against insulin. Treatment options include dietary modifications, glucocorticoids, azathioprine, rituximab and plasmapheresis.Case report: A 72-year-old woman with no medical ...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common feature of type 2 diabetes mellitus (T2DM). Liver fibrosis has been associated with an increased risk of cardiovascular diseases (CVD).Aim: To investigate whether the fibrosis 4 index (FIB-4), a non-invasive marker of liver fibrosis, is associated with CVD or cancer in patients with T2DM.Methods: Two hundred and nine consecutive T2DM patients...